Chlordiazepoxide

Anxiolytic agent (tranquilizer) from benzodiazepine group.

Enhances the inhibitory effect of GABA (a mediator of pre- and post-synaptic inhibition in all parts of the CNS) on the transmission of nerve impulses.Stimulates benzodiazepine receptors located in the allosteric center of the post-synaptic GABAA receptors of the ascending reticular formation of the brainstem and lateral spinal cord insertion neurons; decreases the excitability of subcortical structures of the brain (limbic system, thalamus, hypothalamus), inhibits polysynaptic spinal reflexes.Anxiolytic action is caused by the influence on the almond complex of the limbic system and manifests itself in the reduction of emotional tension, weakening of anxiety, fear, anxiety.Sedative effect is caused by influence on reticular formation of brain stem and non-specific thalamic nuclei and is manifested in reduction of neurotic symptoms (anxiety, fear). It has a pronounced sedative effect.The main mechanism of sleeping pills is the suppression of reticular formation cells of the brain stem. Reduces the impact of emotional, vegetative and motor stimuli that disturb the mechanism of sleep. During the first 3-5 days of intake, it may have a moderate sleeping pills effect (makes it easier to fall asleep), as well as a slight decrease in BP.It causes moderate muscle relaxation and has a weak antiepileptic effect.The central myorelaxing effect is due to the inhibition of polysynaptic spinal afferent inhibitory pathways (to a lesser extent monosynaptic). Direct inhibition of motor nerves and muscle function is also possible.Anticonvulsant action is realized by strengthening presynaptic inhibition.The spread of epileptic activity is suppressed, but the excited focus state is not removed.Suppresses central sympathetic effects, has antiarrhythmic effect. Causes relaxation of the uterus muscles, has antihypoxic properties (including myocardial infarction).

How to use chlordiazepoxide DosageFor adults: Inside, adults – 5-25 mg 3-4 times a day, weakened patients and elderly patients – 5-10 mg 2-4 times a day, if necessary and taking into account tolerance, the dose is gradually increased.In a state of tension and anxiety, combined with insomnia – 10-20 mg 1 time 1-2 hours before sleep.In psychiatric practice – initially 50-100 mg per day, then https://pillintrip.com/medicine/chlordiazepoxide the dose is gradually increased to 300 mg per day, which is divided into 3-4 doses.Premedication – 5-10 mg 3-4 times a day, starting 1 day before surgery.Alcohol withdrawal – the initial dose of 50-100 mg, if necessary, repeated in the same dose after 2-4 hours, the maximum dose of 400 mg / day, then the dose is reduced to a maintenance level.For children aged 6-7 years – 5-10 mg/day, 8-14 years – 10-20 mg/day, 15-18 years – 20-30 mg/day. The daily dose is always divided into 3-4 single doses.

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