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Olopatadine


Composition and shape of issue
Eye drops - 1 ml:

Active substance: opatadine hydrochloride - 1.11 mg (corresponds to 1.0 mg of opatadine);
Auxiliaries: benzalkonium chloride, sodium chloride, dodecagidrate phosphate dynatrium; concentrated chloride acid and/or sodium hydroxide (to bring pH), purified water.

Patanol dosage a transparent or slightly opalescent solution from colourless to pale yellow.

Pharmacological action
A selective histamine H1-receptor blocker also inhibits the release of inflammation mediators from the mast cells. Has a pronounced antiallergic effect.

It has no effect on α-adrenor receptors, dopamine receptors, m1- and m2-cholinoreceptors, as well as serotonin receptors.
In local applications, system absorption patanol
 
Pharmacokinetics .
In local applications, system absorption patanol is low. Cmax olopatadine in plasma is achieved within 2 h and ranges from 0.5 ng/ml and less to 1.3 ng/ml. T1/2 in plasma is 3 h. It is mainly produced by kidneys. 60-70% - in unchanged form.
 
Pharmacodynamics
Olopatadine is a selective inhibitor patanol overdose of histamine H1-receptors and inhibits the release of inflammatory mediators from the mast cells. It has a pronounced anti-allergic effect. It has no effect on alpha-adrenergic, dopamine, muscarinic types 1 and 2, as Dmitry Sazonov well as serotonin receptors.In local applications, system absorption patanol


Indications for use

Allergic conjunctivitis.

Contraindications to use
Hypersensitivity to the ingredients of the drug.
 
Use in pregnancy and children
There is no sufficient experience in using the drug during pregnancy and lactation (breastfeeding). Use in Dmitry Sazonov pregnant and breastfeeding women is possible when the expected therapeutic effects exceed the potential risk of side effects in the fetus or the baby.In local applications, system absorption patanol

There is no sufficient experience with the drug in children under 3 years of age. Opathanolwww.accessdata.fda.gov/drugsatfda_docs/label/2003/20688slr016_patanol_lbl.pdf can be administered to children 3 years of age or older in the same doses as for adults.

Side effects
Local reactions: less than 5% - blurred vision, burning and pain in the eyes, tears,https://reference.medscape.com/drug/pataday-patanol-olopatadine-ophthalmic-343635 feeling of a foreign body in the eye, conjunctival hyperemia, keratitis, irrit, swelling of the eyelids.